THE 2026 GLP-1 RANKING
Every GLP-1, ranked
We evaluate branded GLP-1 medications on efficacy, tolerability, evidence, and treatment practicality. See how we score →
| # | Medication | MD score | Avg. loss | Dosing | |
|---|---|---|---|---|---|
| 1 | Zepbound® (tirzepatide)Editor's Pick Dual GIP + GLP-1 · weekly injection | 9.4 | 21% | Weekly | Review → |
| 2 | Wegovy® (semaglutide)Most studied GLP-1 · weekly injection | 9.1 | 15% | Weekly | Review → |
| 3 | Saxenda® (liraglutide) GLP-1 · daily injection | 7.2 | 8% | Daily | Review → |
| 4 | Wegovy® tablets (oral semaglutide)No needles GLP-1 · daily pill | 6.8 | 14% | Daily | Review → |
*FDA approval applies to specific drug products, formulations, and indications—not broadly to every product containing the same active ingredient. Compounded versions of these medications are not FDA-approved.